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|Authors: ||杉﨑, えり子|
|Issue Date: ||2018-03-11|
|Abstract: || The hippocampus located inside the temporal lobe plays an important role in learning and memory, thus, it has been widely experimented by researchers using hippocampal tissues. Especially, the synaptic plasticity, the foundational phenomenon for learning and memory observed at the cell level, is largely investigated and clarified in details. Meanwhile, acetylcholine （ACh） is released from the cholinergic terminals that project from the medial septum to the hippocampus during attentional processes, resulting in the enhancement of synaptic plasticity. In this review, what kinds of ACh effects influence on the spike timing-dependent plasticity （STDP）, and which ACh receptors on which neurons highly contribute to the STDP are mainly addressed. In addition, underlying mechanisms of the enhancement of STDP induction in the presence of ACh is discussed as well; the direction of STDP is regulated by muscarinic ACh receptors while the amplitude of that is sensitively fine-tuned by nicotinic ACh receptors. Finally, a new finding of the relationship between ACh and the dynamics of membrane potentials during the synaptic changes led by the STDP-inducing stimuli is introduced as one of the related factors for the enhancement of STDP induction in the presence of ACh.|
|Appears in Collections:||第11号|
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