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このアイテムを引用あるいはリンクする場合は次の識別子を使用してください: http://hdl.handle.net/11078/47

タイトル: NON-STATIONARY NOISE ANALYSIS AND SYNAPTIC TRANSMISSION
著者: Hiroshi, Kojima
キーワード: non-stationary noise analysis
glutamate receptor
single channnel
Purkinje cell
発行日: 2013-03-31
抄録: Non-stationary noise analysis is one of the most significant methods to estimate single channel conductance of receptor channels that mediate postsynaptic currents at the synapses in the central nervous system. In the present article, the principle of the peak-scaled fluctuation analysis is described in the context of synaptic transmission between neurons. Furthermore, this fluctuation analysis is applied to glutamate receptor channnel in order to investigate the properties of AMPA receptor channels which underlay long-term change in synaptic strength, which is thought to be substrate of memory and learning in the brain, observed in cerebellar Purkinje cell. Whole cell patch clamp technique was used to measure the synaptic currents from Purkinje cell by parallel fiber activation. The decay phases of the postsynaptic currents were approximated by a single exponential function. The mean current and variance relationship was fitted with the parabolic curves to estimate the single channel conductance. It was suggested that no change in single channel conductance was observed before and during LTD.
URI: http://hdl.handle.net/11078/47
ISSN: 0371-5981
出現コレクション:04. 工学部紀要

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